《英文msh詞典》TLS Protein
[入口詞] TLS Protein
[主題詞] RNA-Binding Protein FUS
[英文釋義] A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator,while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS,FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA,MYXOID) and acute myeloid leukemia.